When should fortification of human milk or formula generally be considered for cessation?

Fortification of human milk or infant formula is generally considered necessary to meet the nutritional needs of preterm infants who require additional calories and nutrients for optimal growth and development. The decision to cease fortification is typically based on the infant's gestational age, growth parameters, and overall health.

Around 34 weeks postmenstrual age (gestational age plus chronological age), many preterm infants begin to mature in their ability to tolerate and absorb nutrients effectively. By this stage, they may have sufficient body reserves and growth patterns indicating that they no longer require the additional calories and nutrients provided by fortified milk or formula. Infants have typically developed better feeding skills and are usually able to meet their nutritional needs through standard breast milk or formula alone.

Monitoring growth closely during this period aids clinicians in making informed decisions. If an infant shows consistent weight gain and grows appropriately for their age, it can be a signal that fortification may no longer be necessary. This approach helps ensure that preterm infants are transitioned back to standard milk without risking nutritional deficits.