What is the maximum duration of action for intermediate-acting insulin?

Intermediate-acting insulin, such as NPH insulin, is designed to provide a duration of action that typically lasts up to 24 hours. This class of insulin is formulated to have a slower onset and a more prolonged glycemic effect compared to short-acting insulins. The peak effect usually occurs between 4 to 12 hours after administration, supporting a sustained level of insulin in the bloodstream that helps maintain blood glucose control throughout the day.

The duration of action being up to 24 hours makes intermediate-acting insulin suitable for use in certain therapeutic regimens, particularly for patients who require coverage of their basal insulin needs over a longer period but still want the flexibility for meal-time coverage that shorter-acting insulins might provide.

Understanding the pharmacokinetics of different types of insulin is crucial for effective diabetes management, and recognizing the characteristics of intermediate-acting insulin helps healthcare professionals tailor individualized treatment plans for their patients.