What is the consequence of impaired fat absorption in cholestatic liver disease?

Impaired fat absorption in cholestatic liver disease leads to a deficiency of fat-soluble vitamins. This occurs because the digestive process relies on bile acids to emulsify fats, which aids in their absorption in the intestines. In cholestatic liver disease, bile flow is obstructed or impaired, resulting in insufficient bile reaching the intestines. This disrupts the digestion and absorption of dietary fats, including essential fatty acids and fat-soluble vitamins, which are vitamins A, D, E, and K.

When these fat-soluble vitamins are not adequately absorbed, individuals can experience a range of health issues associated with their deficiencies. For example, vitamin A deficiency can lead to vision problems, vitamin D deficiency can result in bone disorders such as rickets in children, and vitamin K deficiency can affect blood clotting. These deficiencies underscore the significant consequences that can arise from disrupted fat absorption linked to cholestatic liver disease.